Research progress on the pathogenesis of arthritis

Abstract

Juvenile Idiopathic Arthritis (JIA) pathogenesis is not very clear, but it may be associated with specific components of various infectious microorganisms as foreign antigens for people with a genetic background, activate immune cells, and trigger an abnormal immune response by directly damaging or secreting cytokines, autoantibodies. Cause damage and degeneration of our own organization. Especially certain bacteria, viruses, special components (such as HSP) can be used as superantigens, T cells are activated directly by binding to T cell receptors (TCR) with a special variable region β chain (chain) structure and stimulate immune damage. Self-tissue denaturing components (endogenous antigens), can also be used as an antigen to trigger an immune response to its own tissue components. Further aggravate the immune damage. Intestinal microbial groups and environmental factors may also play an important role in the pathogenesis of JIA.