THE RELATIONSHIP BETWEEN MEAN PLATELET VOLUME AND CORONARY COLLATERAL VESSELS IN PATIENTS WITH ACUTE CORONARY SYNDROMES

Abstract

Background: Elevated mean platelet volume (MPV) has been proposed as a risk factor for coronary artery disease (CAD) and is associated with poor clinical outcomes in acute coronary syndrome (ACS). However, some studies have contradictory findings. Hence we aimed to evaluate the association of MPV with the presence of coronary collateral vessels (CCV) in patients with ACS.
Objective: To find MPV value in ACS patients and to find the predictive value of MPV in the spectrum of CAD and to examine whether levels of MPV predict the presence of CCVs.
Methods: A total of 180 patients with first ACS were included in the study. Mean platelet volume (MPV) was measured. All patients underwent coronary angiography to know disease severity and coronary collateral vessels (CCVs). The CCVs are graded according to the Rentrop scoring system and According to coronary angiography results, patients were divided into two groups as Group 1 (poor CCV) and Group 2 (good CCV).
Results: The mean MPV was 10.74 ± 2 fl in poor collaterals group patients and 11.01 ±1.7 fl in good collaterals group (p-value 0.421). The presence of CCV was not significantly associated with high levels of MPV. MPV value did not show any prediction of the spectrum of coronary artery disease.
Conclusion: MPV on admission was not associated with the development of CCV positively in patients with ACS. Also, it is not associated with the number of vessel involvements.
KEYWORDS: Acute coronary syndrome, Coronary artery disease, Mean platelet volume, Coronary collateral vessels, Rentrop criteria.