GLUCOSE AND LIPID PROFILE IN PREGNANCY INDUCED HYPERTENSION (PIH) IN A LOCAL POPULATION: A CASE CONTROL STUDY

Abstract

Objective: To estimate the lipid profile and glucose level in pregnancy induced hypertensive verses normal pregnant women in local population.

Design: Cross Sectional case control study.  Place & Duration of Study: All biochemical samples were analyzed in Institute of Molecular Biology and Biotechnology (IMBB), UOL from March to December 2012 and Gynecology department of Jinnah hospital Lahore. 

Methods: Total of 60 individuals who consented was divided into case and control groups. The cases included  30 hypertensive pregnant women and controls included 30 normal pregnant women .Blood samples were collected from Gynecology department Jinnah hospital Lahore. Detailed physical examinations were performed. Blood pressure, age and weight were recorded.  

Results: The glucose level was found to be slightly high in hypertensive pregnant women but no significant change was observed in hypertensive (Mean+/-SD: 95.93±14.268 vs. 87.86±17.83). The total cholesterol was  found to be significantly higher in hypertensive pregnant women as compared to normal pregnant women (274.16±37.55 vs. 171.00±30.776).  The TG level significant high in hypertensive then normal group (175.06±32.20 vs. 114.86±20.58) and HDL level low in hypertensive group (49.4±8.15 vs. 55.42±7.98). The LDL  level (171.66±29.98 vs 105.60±19.66) and VLDL level (34.90±6.47 vs. 22.83±4.06).

Conclusions: The women with very high BP had higher Cholesterol, TG, LDL and VDL as compared to pregnant women. In normal pregnant women the level of cholesterol, TG, HDL, LDL and VLDL are normal or slightly raised. For glucose level, it is considered a non-significant risk factor for hypertension.